Immunoproteasome activity

Female sex increases immunoproteasome activity in mice.

“Specifically, old female exhibited higher immunoproteasome activity than old male, despite similar levels of proteasome and immunoproteasome subunit expression and proteasome complex assembly.”

Animalsold female vs old malelymph node

Sex-specific remodeling of proteasome complexes in lymph nodes of aged BTBR mice

Frontiers in aging·6 Jul 2026