IL-6, TNF-alpha, and C4b AEV panel

1. IL-6, TNF-alpha, and C4b AEV panel predicts mild cognitive impairment in humans (AUC > 0.7).

   “ROC analyses indicate that a combined biomarker panel (IL‐6, TNF‐α, and C4b) improves the classification of MCI status (AUC > 0.7).”

   Humansplasma astrocyte-derived small extracellular vesiclesmales

   Inflammatory and Complement Biomarkers of Cognitive Decline in Astrocyte‐Derived Extracellular Vesicles from the Vietnam Era Twin Study of Aging

   AAIC 2025 abstract·9 Jan 2026

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