Aging Cell
Y-chromosome loss linked to later eye disease in men
An observational study of 223,051 UK Biobank men linked Y-chromosome loss in blood cells to later age-related macular degeneration.An observational study of 223,051 UK Biobank men linked Y-chromosome loss in blood cells to later age-related macular degeneration.
Cohort · 223,051 peopleEye
Who was studied223,051 male UK Biobank participants, 15-year follow-up
What changedMen with less Y-chromosome loss had lower macular degeneration risk (hazard ratio 0.611)
The catchThe Y-chromosome assay misses low-level chromosome loss and complex structural variations