medRxiv
Combined sleep and smell signs linked to Parkinson’s marker
A spinal-fluid test was positive in 94% with a confirmed dream-enactment sleep disorder and reduced smell, versus 40% with the disorder but no reduced smell.A spinal-fluid test was positive in 94% with a confirmed dream-enactment sleep disorder and reduced smell, versus 40% with the disorder but no reduced smell.
Preprint: cohort · 1,652 peopleParkinson's disease
Who was studied1,652 adults with REM sleep behavior disorder or hyposmia
What changedParkinson’s marker positivity was higher with smell loss and dream enactment: 84.7% versus 55.1% with smell loss alone
The catchRestricting smell-loss groups to lower dopamine transporter binding inflated their marker positivity
