Hippocampal atrophy rate

1. DNA methylation signatures are associated with hippocampal atrophy rate in humans (>10% of variation).

   “Baseline methylation at these loci was significantly associated with rates of bilateral hippocampal loss over time, explaning over 10% of the variation in hippocampal atrophy rates.”

   Humansbloodn = 8,156

   Integrative cross‐omics analysis identifies DNA methylation signatures associated with bilateral hippocampal volume, asymmetry and atrophy rate in the general population

   AAIC 2025 abstract·24 Dec 2025

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