Gpnmb and Pmel expression

There is 1 paper on Gpnmb and Pmel expression in aging research: none in people yet, 1 in animals.

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TREM2R47HVARIANT

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TREM2R47HVARIANT decreases Gpnmb and Pmel expression in App NL-F knock-in mice; trend in part of comparisons.
“Pmel and Gpnmb were or tended to be downregulated in Trem2 R47H KI as well as in Trem2 KO mice”
Animalsin App NL-F knock-in mice; trend in part of comparisons
Trem2 R47H mutation shows mild, but functionally divergent alterations in microglial phenotypes compared to Trem2 deficiency in aged App NL-F knock-in mice
bioRxiv (Cold Spring Harbor Laboratory)May 21, 2026Preprint

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bioRxivMay 21

Trem2 R47H mutation shows mild, but functionally divergent alterations in microglial phenotypes compared to Trem2 deficiency in aged App NL-F knock-in mice

Preprint: experiments in miceTREM2