Amyloid-β42 accumulation

1. TREM2 decreases amyloid-β42 accumulation in mice (shown by knockout in App NL-F knock-in mice).

   “Accumulation of amyloid β 42 and formation of dystrophic neurites were increased in Trem2 KO mice but not in Trem2 R47H KI mice at 18 or 24 months.”

   Animalsshown by knockout in App NL-F knock-in mice

   Trem2 R47H mutation shows mild, but functionally divergent alterations in microglial phenotypes compared to Trem2 deficiency in aged App NL-F knock-in mice

   bioRxiv (Cold Spring Harbor Laboratory)·May 21, 2026Preprint

More on TREM2