G8 score

1. G8 score showed no clear effect on overall survival in humans (older adults with head and neck cancer).

   “The frailty risk (G8 score) was not associated with 2-year OS.”

   Human trialolder adults with head and neck cancer2 yearsn = 475

   Patient-related prognostic factors in older adults with head and neck cancer: The EGeSOR clinical trial

   European journal of cancer (Oxford, England : 1990)·Jul 10, 2025

1. G8 score predicts mortality in humans (solid tumors) (AUC 0.65, C-index 0.60).

   “outperforming the G8 score (AUC 0.65; C-index 0.60) and Balducci's classification (AUC 0.58; C-index 0.56) (all pairwise p < 0.001).”

   Humanssolid tumorsn = 822

   Prognostic assessment in older adults with solid tumors: A multicenter comparison of Onco-MPI, Balducci's classification, and G8 score

   Journal of geriatric oncology·Jul 9, 2026

2. G8 score predicts mortality in humans (newly diagnosed prostate cancer) (HR 2.9, 95% CI 1.8-4.5, AUC 0.715).

   “Defining frailty as the presence of comorbidities (CCI ≥ 1 point) shows inferior (HR:1.3, 95% CI: 0.8-2.1-AUC: 0.583) accuracy compared to the G8-score (HR 2.9, 95% CI 1.8-4.5-AUC: 0.715).”

   Humansnewly diagnosed prostate cancermalesn = 182

   A Multi-Center Comparative Analysis of the G8-Score and Charlson Comorbidity Index as General Health Assessment Tools in Older Patients With Prostate Cancer

   Clinical genitourinary cancer·Oct 17, 2025

3. G8 score predicts mortality in humans (univariate Cox model) (HR: 2.35, 95% CI 1.53-3.60, p < 0.001).

   “for the G8-score (HR: 2.35, 95% CI 1.53-3.60, p < 0.001)”

   Humansunivariate Cox modeln = 197

   Combining the HCT-CI, G8, and AML-Score for Fitness Evaluation of Elderly Patients with Acute Myeloid Leukemia: A Single Center Analysis

   Cancers·Feb 4, 2023

4. G8 score predicts mortality in humans (mCRPC treated with ARPIs) (p < 0.001 and p = 0.004).

   “independent prognostic factors for both worse rPFS and OS were Geriatric G8 assessment ≤ 14”

   HumansmCRPC treated with ARPIsmalesn = 234

   The Geriatric G8 Score Is Associated with Survival Outcomes in Older Patients with Advanced Prostate Cancer in the ADHERE Prospective Study of the Meet-URO Network

   Current oncology (Toronto, Ont.)·Oct 14, 2022

5. G8 score predicts mortality in humans (endometrial cancer) (HR: 4.58; 95% CI [1.35-15.51]).

   “only the G8 Score retained independent significance as a prognostic factor for disease-specific survival (DSS) (HR:4.58; 95% CI [1.35-15.51])”

   Humansendometrial cancerfemalesn = 153

   The preoperative G8 geriatric screening tool independently predicts survival in older patients with endometrial cancer: results of a retrospective single-institution cohort study

   Journal of cancer research and clinical oncology·Feb 25, 2022

1. Handgrip strength is associated with G8 score in humans (hospitalized oncology patients; reduced handgrip strength) (p < 0.001).

   “Reduced handgrip strength was associated with lower G8 scores (p < 0.001) and lower G8 item C mobility scores (p = 0.001).”

   Humanshospitalized oncology patients; reduced handgrip strengthn = 116

   CT-Derived L3 Skeletal Muscle Index, Handgrip Strength, and Nutritional Behavior as Complementary Dimensions of Frailty in Older Oncology Inpatients: A Cross-Sectional Observational Study

   Nutrients·Oct 28, 2026

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1. G8 score is associated with treatment side effects in humans (Patients with hepatocellular carcinoma receiving sorafenib).

   “Additionally, worse G8 scores were correlated with greater side effects after 3 months of treatment.”

   HumansPatients with hepatocellular carcinoma receiving sorafenib3 months

   G8 Frailty Assessment Tool as a Predictor of Quality of Life in Elderly Patients Receiving Sorafenib for Hepatocellular Carcinoma. A Prospective Cohort

   European Journal of Geriatrics and Gerontology·Mar 3, 2026

1. G8 score is associated with quality of life in humans (Patients with hepatocellular carcinoma receiving sorafenib; most follow-up encounters).

   “Moreover, lower G8 scores were significantly correlated with worse QoL subscale scores during most follow-up encounters.”

   HumansPatients with hepatocellular carcinoma receiving sorafenib; most follow-up encounters3 months

   G8 Frailty Assessment Tool as a Predictor of Quality of Life in Elderly Patients Receiving Sorafenib for Hepatocellular Carcinoma. A Prospective Cohort

   European Journal of Geriatrics and Gerontology·Mar 3, 2026

1. G8 score is associated with physical function in humans (Patients with hepatocellular carcinoma receiving sorafenib).

   “A worse G8 score was significantly associated with poorer physical function, as measured by TUGT, in all three encounters.”

   HumansPatients with hepatocellular carcinoma receiving sorafenib3 months

   G8 Frailty Assessment Tool as a Predictor of Quality of Life in Elderly Patients Receiving Sorafenib for Hepatocellular Carcinoma. A Prospective Cohort

   European Journal of Geriatrics and Gerontology·Mar 3, 2026

1. G8 score predicts urinary continence recovery in humans after robot-assisted radical prostatectomy (OR 1.56, P < 0.05).

   “Multivariable analysis showed age (3-month odds ratio (OR) 0.973, 1-year OR 0.947), nerve-sparing (3-month OR 2.39, 1-year OR 1.77), and low frailty (3-month OR 1.56, 1-year OR 1.75) as significant factors affecting continence recovery”

   Humansafter robot-assisted radical prostatectomy3 monthsmalesn = 1,794

   Association of the G8 score with urinary continence recovery after robot-assisted radical prostatectomy

   World journal of urology·Jan 30, 2026

1. G8 score is associated with Tokyo Metropolitan Institute of Gerontology Index of Competence in humans (stage 0-III NSCLC post-surgery).

   “Conversely, a low G8 score was sole factor associated with a decline in the TMIG-IC score after 24 months.”

   Humansstage 0-III NSCLC post-surgery24 monthsn = 876

   Longitudinal assessment of functional independence of older adults after lung cancer surgery: Final results of the JCOG1710A prospective cohort study

   Journal of geriatric oncology·May 30, 2025

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1. G8 score predicts lifespan in humans (endometrial cancer) (HR: 2.89; 95% CI [1.31-6.39]).

   “overall survival (OS) (HR:2.89; 95% CI [1.31-6.39]”

   Humansendometrial cancerfemalesn = 153

   The preoperative G8 geriatric screening tool independently predicts survival in older patients with endometrial cancer: results of a retrospective single-institution cohort study

   Journal of cancer research and clinical oncology·Feb 25, 2022

1. G8 score is associated with Charlson Comorbidity Index in humans (urological conditions) (p < 0.05).

   “Both tests correlated significantly with the Charlson comorbidity index, length of stay, number of coded diagnosis, and Braden score (p < 0.05).”

   Humansurological conditionsn = 100

   Comparison of G8 and ISAR Screening Results in Geriatric Urology

   Medicines (Basel, Switzerland)·Jul 22, 2021

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1. G8 score is associated with ISAR score in humans (urological conditions) (r = -0.77, p < 0.001).

   “There was a significant negative correlation between the G8 and ISAR scores (r = -0.77, p < 0.001).”

   Humansurological conditionsn = 100

   Comparison of G8 and ISAR Screening Results in Geriatric Urology

   Medicines (Basel, Switzerland)·Jul 22, 2021

More on ISAR score