Five-protein predictive signature

1. Five-protein predictive signature predicts incident metabolic dysfunction-associated steatotic liver disease in humans (5-year AUC 0.838; 16.6-year AUC 0.756; EPIC-Norfolk 16.6-year AUC 0.710; Southern China Inception Cohort AUC 0.912).

   “Our five-protein model achieves predictive accuracy of 0.838 (5 year area under the curve (AUC)) and 0.756 (16.6 year AUC)”

   Humansplasma16.6 yearsn = 50,000

   Plasma proteomics framework predicts metabolic dysfunction-associated steatotic liver disease up to 16 years before onset

   Nature aging·30 Jul 2026

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