Expanded mosaic chromosomal alterations

1 paper4 findings

Associations

Respiratory disease mortality

upin humans1HR 1.24

1 study

Expanded mosaic chromosomal alterations are associated with respiratory disease mortality in humans (HR 1.24, 95% CI 1.12–1.37).
“1.27 [1.21, 1.34], 1.13 [1.02, 1.25], and 1.24 [1.12, 1.37] for death from cancers, circulatory diseases, and respiratory diseases, respectively”
HumansExpanded mCAs defined as cell fraction ≥ 10%; combined estimates from two prospective cohortsMedian follow-up: 17.2 years in CKB and 13.7 years in UKB
Expanded mosaic chromosomal alterations, frailty, and risks of all-cause and cause-specific mortality among Chinese and the UK adults: evidence from two prospective cohorts
BMC medicine11 Nov 2025

Circulatory disease mortality

upin humans1HR 1.13

1 study

Expanded mosaic chromosomal alterations are associated with circulatory disease mortality in humans (HR 1.13, 95% CI 1.02–1.25).
“1.27 [1.21, 1.34], 1.13 [1.02, 1.25], and 1.24 [1.12, 1.37] for death from cancers, circulatory diseases, and respiratory diseases, respectively”
HumansExpanded mCAs defined as cell fraction ≥ 10%; combined estimates from two prospective cohortsMedian follow-up: 17.2 years in CKB and 13.7 years in UKB
Expanded mosaic chromosomal alterations, frailty, and risks of all-cause and cause-specific mortality among Chinese and the UK adults: evidence from two prospective cohorts
BMC medicine11 Nov 2025

Cancer mortality

upin humans1HR 1.27

1 study

Expanded mosaic chromosomal alterations are associated with cancer mortality in humans (HR 1.27, 95% CI 1.21–1.34).
“1.27 [1.21, 1.34], 1.13 [1.02, 1.25], and 1.24 [1.12, 1.37] for death from cancers, circulatory diseases, and respiratory diseases, respectively”
HumansExpanded mCAs defined as cell fraction ≥ 10%; combined estimates from two prospective cohortsMedian follow-up: 17.2 years in CKB and 13.7 years in UKB
Expanded mosaic chromosomal alterations, frailty, and risks of all-cause and cause-specific mortality among Chinese and the UK adults: evidence from two prospective cohorts
BMC medicine11 Nov 2025

Mortality

upin humans1HR 1.2

1 study

Expanded mosaic chromosomal alterations are associated with mortality in humans (HR 1.20, 95% CI 1.16–1.24).
“expanded mCAs carriers had a higher risk of all-cause (HRs [95% CIs]: 1.20 [1.16, 1.24])”
HumansExpanded mCAs defined as cell fraction ≥ 10%; combined estimates from two prospective cohortsMedian follow-up: 17.2 years in CKB and 13.7 years in UKB
Expanded mosaic chromosomal alterations, frailty, and risks of all-cause and cause-specific mortality among Chinese and the UK adults: evidence from two prospective cohorts
BMC medicine11 Nov 2025

1 in 12 months

BMC Medicine11 Nov

Cohort study of 456,283 peopleBiomarkers