Exopher biogenesis

1 paper studies it2 more mention it1 finding

Upstream

1

atg-16.2

is required forin worms1

1 study

atg-16.2 is required for exopher biogenesis in worms.
“ATG-16.2 WD40 domain, a conserved domain critical for at least some noncanonical autophagy functions of ATG16L1 in mammalian cells, is required for the increased exopher biogenesis”
Model organismsneuronal inhibition of early-acting autophagy genesneuron
Neuronal waste management: new roles for autophagy genes in the extrusion of protein aggregates and in longevity
AutophagyFeb 27, 2024

More on atg-16.2

Latest

AutophagyFeb 27

Neuronal waste management: new roles for autophagy genes in the extrusion of protein aggregates and in longevity

ReviewAutophagy

Nature AgingJan 5

Autophagy protein ATG-16.2 and its WD40 domain mediate the beneficial effects of inhibiting early-acting autophagy genes in C. elegans neurons

Experiments in wormsAutophagy

bioRxivDec 14

Inhibition of early-acting autophagy genes in C. elegans neurons improves protein homeostasis, promotes exopher production, and extends lifespan via the ATG-16.2 WD40 domain

Preprint: experiments in wormsProteostasis