Effective temperature

Effective temperature has no effect on lifespan in silico.

“the overall rate of damage accumulation and hence the maximum lifespan does not depend on the effective temperature driving the noise in leading pathways”

In silicomulti-scale theoretical framework for entropic aging

Discovery of Thermodynamic Control Variables that Independently Regulate Healthspan and Maximum Lifespan

bioRxiv (Cold Spring Harbor Laboratory)·5 Dec 2024Preprint

Effective temperature is associated with survival curve in silico.

“effective temperature does influence both initial mortality rate and the mortality rate doubling time – thereby shaping the survival curve.”

In silicomulti-scale theoretical framework for entropic aging

Discovery of Thermodynamic Control Variables that Independently Regulate Healthspan and Maximum Lifespan

bioRxiv (Cold Spring Harbor Laboratory)·5 Dec 2024Preprint

Effective temperature is associated with magnitude of fluctuations across biological pathways in silico.

“We discovered a single species-dependent scaling factor controlling the magnitude of fluctuations across biological pathways.”

In silicomulti-scale theoretical analysis of mammalian DNA methylation data

Discovery of Thermodynamic Control Variables that Independently Regulate Healthspan and Maximum Lifespan

bioRxiv (Cold Spring Harbor Laboratory)·5 Dec 2024Preprint