DNA methylation-based telomere length

1. DNA methylation-based telomere length is associated with mortality in humans.

   “one kilobase decrease in DNAmTL was associated with a 40% increase in mortality risk”

   HumansPer one kilobase decrease in DNAmTL; the reported HR and verbal percentage increase have inconsistent directions

   DNA methylation-based telomere length is associated with HIV infection, physical frailty, cancer, and all-cause mortality

   Aging cell·Apr 17, 2024

1. Cancer is associated with DNA methylation-based telomere length in humans (β = -0.07, 95% CI -0.10 to -0.03).

   “higher cancer prevalence [beta = -0.07 (-0.10, -0.03), p = 1.37E-04 without adjusting age] were associated with shortened DNAmTL.”

   HumansWithout adjusting for age

   DNA methylation-based telomere length is associated with HIV infection, physical frailty, cancer, and all-cause mortality

   Aging cell·Apr 17, 2024

More on Cancer

1. VACS Index is associated with DNA methylation-based telomere length in humans (β = -0.002, 95% CI -0.003 to -0.001).

   “In summary, HIV infection, physiologic frailty, and cancer are associated with shortening DNAmTL, contributing to an increased risk of all-cause mortality.”

   HumansHigher VACS Index, a measure of physiologic frailty

   DNA methylation-based telomere length is associated with HIV infection, physical frailty, cancer, and all-cause mortality

   Aging cell·Apr 17, 2024

More on VACS Index

1. HIV infection is associated with DNA methylation-based telomere length in humans (β = -0.25, 95% CI -0.32 to -0.18).

   “We found that people with HIV had shorter average DNAmTL than those without HIV infection”

   HumansPeople with HIV compared with people without HIVwhole blood or peripheral blood mononuclear cells

   DNA methylation-based telomere length is associated with HIV infection, physical frailty, cancer, and all-cause mortality

   Aging cell·Apr 17, 2024

More on HIV infection