Distribution of removed versus retained DNA methylation beta values

detection p-value and bead count thresholds are associated with distribution of removed versus retained DNA methylation beta values in silico.

“both detection p-value and bead count thresholds remove beta values that differ significantly in their distribution from the values retained post-QC.”

In silicoQuality control using detection p-value and bead count thresholds

DNA methylation quality control decisions, removed beta values, and their influence on epigenetic clocks

Epigenomics·20 Jul 2026