Deacetylation of the SIRT1 substrate P53

1. CD38 decreases deacetylation of the SIRT1 substrate P53 in mice.

   “in vivo deacetylation of the SIRT1 substrate P53 is increased in CD38 knockout mice tissue.”

   Animalsknockout of Cd38

   Regulation of SIRT 1 mediated NAD dependent deacetylation: a novel role for the multifunctional enzyme CD38

   Biochemical and biophysical research communications·22 Aug 2006

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