D2/D3 receptor availability

D2/D3 receptor availability is associated with reward-related memory performance in humans.

“higher midbrain (substantia nigra and ventral tegmental area) D2/D3 availability which was linked to poorer reward-related memory performance.”

HumansHealthy older adultsMidbrain: substantia nigra and ventral tegmental arean = 33

Different dopaminergic circuits defined by D2/D3 receptor availablity patterns show structure-specific links to memory in ageing

bioRxiv (Cold Spring Harbor Laboratory)·22 Jul 2025Preprint

D2/D3 receptor availability is associated with long-delay recognition memory in humans.

“greater D2/D3 receptor availability in the amygdala was associated with better recognition at longer delays.”

HumansHealthy older adultsamygdalaApproximately 24 hoursn = 33

Different dopaminergic circuits defined by D2/D3 receptor availablity patterns show structure-specific links to memory in ageing

bioRxiv (Cold Spring Harbor Laboratory)·22 Jul 2025Preprint

D2/D3 receptor availability is associated with short-term false memories in humans.

“Greater thalamic D2/D3 receptor availability correlated with fewer short-term false memories”

HumansHealthy older adultsthalamusApproximately 15 minutesn = 33

Different dopaminergic circuits defined by D2/D3 receptor availablity patterns show structure-specific links to memory in ageing

bioRxiv (Cold Spring Harbor Laboratory)·22 Jul 2025Preprint

D2/D3 receptor availability predicts long-term memory retention in humans.

“higher putamen D2/D3 predicted more durable long-term memory retention.”

HumansHealthy older adultsputamenApproximately 24 hoursn = 33

Different dopaminergic circuits defined by D2/D3 receptor availablity patterns show structure-specific links to memory in ageing

bioRxiv (Cold Spring Harbor Laboratory)·22 Jul 2025Preprint

D2/D3 receptor availability is associated with liberal recognition response bias in humans.

“Higher caudate D2/D3 receptor availability was associated with a liberal response bias (increased hits and false alarms both)”

HumansHealthy older adultscaudaten = 33

Different dopaminergic circuits defined by D2/D3 receptor availablity patterns show structure-specific links to memory in ageing

bioRxiv (Cold Spring Harbor Laboratory)·22 Jul 2025Preprint