CSF biomarker profile of neuroinflammation, neurodegeneration, and synaptic dysfunction

Older age is associated with CSF biomarker profile of neuroinflammation, neurodegeneration, and synaptic dysfunction in humans.

“Older age was associated with a poorer biomarker profile across all analytes (Ps ≤ 0.03).”

HumansCognitively unimpaired, Alzheimer disease risk-enriched cohortcerebrospinal fluidn = 454

KLOTHO KL-VS heterozygosity is associated with diminished age-related neuroinflammation, neurodegeneration, and synaptic dysfunction in older cognitively unimpaired adults

Alzheimer's & dementia : the journal of the Alzheimer's Association·Jun 21, 2024