CSF biomarkers of neuroinflammation, neurodegeneration, and synaptic dysfunction

1. KL is associated with CSF biomarkers of neuroinflammation, neurodegeneration, and synaptic dysfunction in humans.

   “Higher levels of neuroinflammation, neurodegeneration, and synaptic dysfunction in older adults were attenuated in KL-VSHET.”

   HumansKL-VS heterozygosity in cognitively unimpaired adultscerebrospinal fluid

   KLOTHO KL-VS heterozygosity is associated with diminished age-related neuroinflammation, neurodegeneration, and synaptic dysfunction in older cognitively unimpaired adults

   Alzheimer's & dementia : the journal of the Alzheimer's Association·Jun 21, 2024

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