Crus II gray matter volume

Crus II gray matter volume mediates grip strength in humans (34.4-41.4% mediated).

“Crus II volume partially mediated age effects on grip (34.4-41.4%).”

HumansStatistical mediation of age effects in healthy adultsCerebellar Crus IIn = 304

Quantifying Dexterity and Grip Strength Associations between Age, Cognitive Function (MoCA), and Cerebellar Gray Matter Volume in Healthy Adults across the Adult Lifespan

Research square·23 Jul 2026Preprint

Grip strength is associated with Crus II gray matter volume in humans (r=.156-.224, all p FDR≤.038).

“Grip strength was not associated with any MoCA measure but correlated bilaterally with Crus II GMV (r=.156-.224, all p FDR≤.038).”

HumansHealthy adults; partial correlations adjusted for age, sex, and raceBilateral cerebellar Crus IIn = 304

Quantifying Dexterity and Grip Strength Associations between Age, Cognitive Function (MoCA), and Cerebellar Gray Matter Volume in Healthy Adults across the Adult Lifespan

Research square·23 Jul 2026Preprint