Complement component C3

1. Hormone replacement therapy increases complement component C3 in humans.

   “peri/menopausal females on HRT had increased C3 serum concentrations and significant improvement in monocyte phagocytosis.”

   Humansin peri/menopausal femalesfemales

   Age-Associated Inflammatory Monocytes Are Increased in Menopausal Females and Reversed by Hormone Replacement Therapy

   Aging cell·9 Oct 2025

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