What does the research say about common lymphoid progenitor abundance?

Common lymphoid progenitor abundance

There are 2 papers on common lymphoid progenitor abundance in aging research: 1 observational study in people, 1 in animals. The newest story, Nov 3, 2026: “Inhibiting brain neurons restored immune cell production in aged mice”.

Biomarker

2 papers study it2 findings

1 new paper in 30 daysSee all 2

Humans1
Animals1

Interventions

Chemogenetic inhibition of pvn-crh neurons

upin mice1

1 study

Chemogenetic inhibition of pvn-crh neurons increase common lymphoid progenitor abundance in mice.
“Chemogenetic inhibition of aged PVN-CRH neurons or CRH neuron-specific TLR4 ablation restored CLPs and B-cell production in bone marrow”
Animalsbone marrow
Inhibiting brain neurons restored immune cell production in aged mice
Research SquareNov 2, 2026Preprint

More on Chemogenetic inhibition of pvn-crh neurons

Upstream

TLR4

downin mice1

1 study

TLR4 decreases common lymphoid progenitor abundance in mice (shown by CRH neuron-specific TLR4 ablation).
“CRH neuron-specific TLR4 ablation restored CLPs and B-cell production in bone marrow”
Animalsshown by CRH neuron-specific TLR4 ablationbone marrow
Inhibiting brain neurons restored immune cell production in aged mice
Research SquareNov 2, 2026Preprint

Latest

1 paper in 12 months

Research SquareNov 3

Inhibiting brain neurons restored immune cell production in aged mice

In experiments in aged mice, inhibiting specific brain neurons or deleting a gene involved in inflammatory signaling improved the response to a flu vaccine.In experiments in aged mice, inhibiting specific brain neurons or deleting a gene involved in inflammatory signaling improved the response to a flu vaccine.

Preprint: mouse studyBlood and immune system

Paper

PLOS OneJul 2

Human and Murine Hematopoietic Stem Cell Aging Is Associated with Functional Impairments and Intrinsic Megakaryocytic/Erythroid Bias

Cross-sectional study in peopleBlood and immune system