Combination of traditional risk factors

Combination of traditional risk factors improve prediction accuracy for non-communicable chronic disease incidence in humans.

“In our cohort, a statistical model consisting of a combination of traditional risk factors outperforms any model including an epigenetic clock.”

HumansTraditional risk factor model compared with models including an epigenetic clock7-to-9-year follow-upn = 1,108

Traditional disease risk factors outperform epigenetic clocks as predictors of non-communicable disease morbidity in a middle-aged cohort

bioRxiv (Cold Spring Harbor Laboratory)·14 Feb 2026Preprint