Clipped histone H3

1. BRD4 decreases clipped histone H3 in mice.

   “Brd4 deletion increases clipped H3 (cH3) which correlates with the upregulation of senescence-specific genes”

   Animalsshown by deletion (Brd4Δ/Δ)hematopoietic stem/progenitor cells

   Loss of BRD4 induces cell senescence in HSC/HPCs by deregulating histone H3 clipping

   EMBO reports·Aug 31, 2023

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