Circulating cell-free microRNAs

Extreme aging decreases circulating cell-free microRNAs in humans (40.5%-70.3% decrease).

“miR-93-5p, miR-126-3p, and liver-specific miR-122-5p, exhibited significant age-related decreases (40.5%-70.3%), reaching their lowest levels in centenarians.”

Humans

Multiparametric profiling of plasma cell-free nucleic acids in nonagenarians and centenarians highlights age-related differences associated with longevity

GeroScience·29 Nov 2025