Circadian Disruption Index

1. Circadian Disruption Index is associated with depressive symptoms in humans (β = 0.43 PHQ-9 points, p = 0.020).

   “worse depressive symptoms ( β = 0.43 PHQ-9 points, p = 0.020)”

   Humansn = 4,386

   Sleep Disorders Modify the Age-Related Trajectory of Circadian Rest-Activity Rhythms: Evidence from NHANES 2011–2012 Wrist Actigraphy

   medRxiv·1 Jun 2026Preprint

More on Depressive symptoms

1. Circadian Disruption Index is associated with diabetes in humans (β = 3.8 percentage points, p < 0.001).

   “greater diabetes prevalence ( β = 3.8 percentage points, p < 0.001)”

   Humansn = 4,386

   Sleep Disorders Modify the Age-Related Trajectory of Circadian Rest-Activity Rhythms: Evidence from NHANES 2011–2012 Wrist Actigraphy

   medRxiv·1 Jun 2026Preprint

More on Diabetes

1. Circadian Disruption Index is associated with HbA1c in humans (β = 0.089%, p = 0.004).

   “higher HbA1c ( β = 0.089%, p = 0.004)”

   Humansn = 4,386

   Sleep Disorders Modify the Age-Related Trajectory of Circadian Rest-Activity Rhythms: Evidence from NHANES 2011–2012 Wrist Actigraphy

   medRxiv·1 Jun 2026Preprint

More on HbA1c

1. Circadian Disruption Index is associated with body mass index in humans (β = 1.33 kg/m 2 , p < 0.001).

   “CDI was higher in those with a sleep disorder (0.290 vs. 0.131, p < 0.001) and was independently associated with higher BMI ( β = 1.33 kg/m 2 , p < 0.001)”

   Humansn = 4,386

   Sleep Disorders Modify the Age-Related Trajectory of Circadian Rest-Activity Rhythms: Evidence from NHANES 2011–2012 Wrist Actigraphy

   medRxiv·1 Jun 2026Preprint

More on Body mass index

1. Sleep disorders are associated with Circadian Disruption Index in humans (0.290 vs. 0.131, p < 0.001).

   “CDI was higher in those with a sleep disorder (0.290 vs. 0.131, p < 0.001)”

   Humansn = 4,386

   Sleep Disorders Modify the Age-Related Trajectory of Circadian Rest-Activity Rhythms: Evidence from NHANES 2011–2012 Wrist Actigraphy

   medRxiv·1 Jun 2026Preprint

More on Sleep disorders