Chemokine-related gene expression

glutathione metabolism increases chemokine-related gene expression in mice.

“Disrupting the GSH pathway in microglia resulted in downregulation of chemokine-related genes, aberrant morphogenesis, and β-amyloid deposition.”

Animalsshown by disruption of the glutathione pathwaymicroglia

Characterizing the metabolomes of microglia, astrocytes, and neurons in aging and Alzheimer’s brains

bioRxiv (Cold Spring Harbor Laboratory)·6 Feb 2026Preprint

glutathione and polyamine metabolism is associated with chemokine-related gene expression in mice (Strong correlation; coefficient not reported).

“Notably, GSH and polyamine metabolism correlated strongly with chemokine-related gene expression.”

Animalsmicroglia

Characterizing the metabolomes of microglia, astrocytes, and neurons in aging and Alzheimer’s brains

bioRxiv (Cold Spring Harbor Laboratory)·6 Feb 2026Preprint