The Journal of Cell Biology
Weaker chromosome anchors linked to errors in mouse egg cells
Laboratory experiments found lower levels of two proteins at chromosome attachment sites in older mouse egg cells, alongside changes in the fibers that move chromosomes.Laboratory experiments found lower levels of two proteins at chromosome attachment sites in older mouse egg cells, alongside changes in the fibers that move chromosomes.
Animal cell studyMechanisms
Who was studiedMouse oocytes, against control IgG-injected oocytes
What changedChromosome misalignment affected 85% of CENP-A-depleted mouse egg cells, versus none of the controls
The catchReduced satellite DNA signals could reflect chromatin masking rather than actual DNA loss