AgingResearch.NewsJoin free

CD8+CD45RA+CD57+ senescent cells

Biomarker

1 paper studies it2 findings

  • Humans1

Associations

2

Neuroaxonal injury

upin humans1

1 study

  1. CD8+CD45RA+CD57+ senescent cells are associated with neuroaxonal injury in humans.

    “serum levels of circulating neurofilament light chain, a marker of neuroaxonal injury, were positively correlated with the levels of senescent CD8+ T cells, M-MDSC, IL-10 and CXCL-9”

    Humansat pre-lymphodepletion in R/R-BCL patientsserum

    Peripheral blood cellular profile at pre-lymphodepletion is associated with CD19-targeted CAR-T cell-associated neurotoxicity

    Frontiers in immunology

Immune effector cell-associated neurotoxicity syndrome

upin humans1

1 study

  1. Immune effector cell-associated neurotoxicity syndrome is associated with CD8+CD45RA+CD57+ senescent cells in humans (16.50% vs 9.10%).

    “In the pre-LD samples of 21 patients, a significant increase in the percentage of CD8+CD45RA+CD57+ senescent cells (median % value: 16.50% vs 9.10%, p=0.009) and monocytic-myeloid derived suppressor cells (M-MDSC, median % value: 4.4 vs 1.8, p=0.020) was found in ICANS patients.”

    Humansat pre-lymphodepletion in R/R-BCL patientsperipheral bloodn = 21

    Peripheral blood cellular profile at pre-lymphodepletion is associated with CD19-targeted CAR-T cell-associated neurotoxicity

    Frontiers in immunology

More on Immune effector cell-associated neurotoxicity syndrome

Latest

Related