CD4+ senescent T cells

1. INTERLEUKIN-4 antibody decreases CD4+ senescent T cells in mice.

   “IL-4 neutralization reduced CD4+ Tsen percentages and inhibited p38 mitogen-activated protein kinase (MAPK) activation.”

   Animalshouse dust mite (HDM)-induced asthma model

   Type 2 inflammation accelerates CD4⁺ T-cell senescence in asthma

   Journal of Zhejiang University. Science. B·6 Feb 2026

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1. Asthma increases CD4+ senescent T cells in humans.

   “significantly higher percentages of cluster of differentiation 4-positive (CD4+) senescent T cells (Tsens) in asthma patients than in healthy controls”

   Humansasthma patients vs healthy controls

   Type 2 inflammation accelerates CD4⁺ T-cell senescence in asthma

   Journal of Zhejiang University. Science. B·6 Feb 2026

More on Asthma