CD28lo KLRG1hi IL-7Rlo HLA-DRhi CD8+ T cells

1. CD28lo KLRG1hi IL-7Rlo HLA-DRhi CD8+ T cells are associated with immune response in humans (p =0.0494 for IFN-γ, p =0.0358 for TNF-α, p =0.0262 for MIP-1α, p =0.0043 for MIP-1β).

   “Frequencies of these cells were also positively correlated with CMV-stimulated secretion of IFN-γ (p =0.0494), TNF-α (p =0.0358), MIP-1α (p =0.0262), MIP-1β (p =0.0043).”

   HumansCMV-stimulated

   Cytotoxic KLRG1+ IL-7R- effector CD8+ T cells distinguish kidney transplant recipients controlling cytomegalovirus reactivation

   Frontiers in immunology·Feb 14, 2025

More on Immune response

1. CD28lo KLRG1hi IL-7Rlo HLA-DRhi CD8+ T cells lower the risk of cytomegalovirus reactivation in humans (p =0.0163).

   “CD28lo KLRG1hi IL-7R (CD127)lo HLA-DRhi CD8+ T cells present prior to the detection of viremia in CMV-seropositive patients emerged as a key feature distinguishing patients who did or did not undergo CMV reactivation”

   Humansin CMV-seropositive kidney transplant recipients prior to viremia detection

   Cytotoxic KLRG1+ IL-7R- effector CD8+ T cells distinguish kidney transplant recipients controlling cytomegalovirus reactivation

   Frontiers in immunology·Feb 14, 2025

More on Cytomegalovirus reactivation