CAT-high nucleus abundance

1. Rapamycin decreases CAT-high nucleus abundance in flies.

   “CAT-high nuclei accumulated with age and were preferentially reduced by rapamycin, especially in females, consistent with stronger female lifespan extension.”

   Model organismsGreater reduction in femalesdiverse tissuesboth sexess

   Rapamycin Mitigates a Sex-biased Convergent Aging Trajectory

   bioRxiv (Cold Spring Harbor Laboratory)·3 Jul 2026Preprint

More on Rapamycin

1. Age is associated with CAT-high nucleus abundance in flies.

   “CAT-high nuclei accumulated with age”

   Model organismsdiverse tissuesboth sexess

   Rapamycin Mitigates a Sex-biased Convergent Aging Trajectory

   bioRxiv (Cold Spring Harbor Laboratory)·3 Jul 2026Preprint