Carotid-artery intima-media thickness progression

1. Estradiol has no effect on carotid-artery intima-media thickness progression in humans (0.0100 vs 0.0088 mm per year, P=0.29).

   “rates of CIMT progression in the placebo and estradiol groups were similar (0.0088 and 0.0100 mm per year, respectively; P=0.29).”

   Human triallate postmenopausecarotid artery1 mg per daymedian of 5 yearsfemales

   Vascular Effects of Early versus Late Postmenopausal Treatment with Estradiol

   The New England journal of medicine·31 Mar 2016

2. Estradiol decreases carotid-artery intima-media thickness progression in humans (0.0044 vs 0.0078 mm per year, P=0.008).

   “the mean CIMT increased by 0.0078 mm per year in the placebo group versus 0.0044 mm per year in the estradiol group (P=0.008).”

   Human trialearly postmenopausecarotid artery1 mg per daymedian of 5 yearsfemales

   Vascular Effects of Early versus Late Postmenopausal Treatment with Estradiol

   The New England journal of medicine·31 Mar 2016

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