Cardiovascular disease polygenic risk score

1. Cardiovascular disease polygenic risk score raises the risk of cardiovascular disease in humans (aHR 2.00, 95% CI 1.15-3.47).

   “high PRS plus a favorable profile was associated with higher CVD risk (adjusted hazard ratio [aHR], 2.00; 95% confidence interval [CI], 1.15-3.47)”

   Humanshigh PRS plus favorable profile in adults with depression, years 0-55 yearsn = 3,446

   Joint associations of cardiovascular polygenic risk and a health-related risk profile with incident cardiovascular disease among adults with depression: a UK Biobank study

   Frontiers in endocrinology·20 Aug 2026

More on Cardiovascular disease