Brain-predicted age difference
Biomarker1 paper6 findings
One human study associates bipolar disorder, chronic substance use disorder, major depressive disorder, Alzheimer’s disease, schizophrenia and frontotemporal dementia with greater brain-predicted age difference than age-matched controls after age-bias correction.
- Humans1
Associations
6Chronic substance use disorder
upin humans1
1 study
Chronic substance use disorder
upin humans1
Chronic substance use disorder is associated with brain-predicted age difference in humans (+2.91 years).
HumansCompared with age-matched controls after age-bias correctionbrain
Brain age estimates were higher across six disorders · Psychological medicine · 7 Oct 2026
Major depressive disorder
upin humans1
1 study
Major depressive disorder
upin humans1
Major depressive disorder is associated with brain-predicted age difference in humans (+2.76 years).
HumansCompared with age-matched controls after age-bias correctionbrain
Brain age estimates were higher across six disorders · Psychological medicine · 7 Oct 2026
Bipolar disorder
upin humans1
1 study
Bipolar disorder
upin humans1
Bipolar disorder is associated with brain-predicted age difference in humans (+2.08 years).
HumansCompared with age-matched controls after age-bias correctionbrain
Brain age estimates were higher across six disorders · Psychological medicine · 7 Oct 2026
Alzheimer's disease
upin humans1
1 study
Alzheimer's disease
upin humans1
Alzheimer's disease is associated with brain-predicted age difference in humans (+3.24 years).
HumansCompared with age-matched controls after age-bias correctionbrain
Brain age estimates were higher across six disorders · Psychological medicine · 7 Oct 2026
Frontotemporal dementia
upin humans1
1 study
Frontotemporal dementia
upin humans1
Frontotemporal dementia is associated with brain-predicted age difference in humans (+7.61 years).
HumansCompared with age-matched controls after age-bias correctionbrain
Brain age estimates were higher across six disorders · Psychological medicine · 7 Oct 2026
Schizophrenia
upin humans1
1 study
Schizophrenia
upin humans1
Schizophrenia is associated with brain-predicted age difference in humans (+7.64 years).
HumansCompared with age-matched controls after age-bias correctionbrain
Brain age estimates were higher across six disorders · Psychological medicine · 7 Oct 2026
Latest
1Brain age estimates were higher across six disorders
The gap between scan-estimated and actual age exceeded age-matched controls by 7.64 years in schizophrenia and 7.61 years in frontotemporal dementia.The gap between scan-estimated and actual age exceeded age-matched controls by 7.64 years in schizophrenia and 7.61 years in frontotemporal dementia.