Brain epigenetic age acceleration

1. mTOR signaling increases brain epigenetic age acceleration in mice (drug-naive mutant epileptic mouse model) (adjusted p < 0.05).

   “In a drug-naïve mTOR mouse model, mutant epileptic brains, but not blood, showed epigenetic age acceleration (adj. p < 0.05).”

   Animalsdrug-naive mutant epileptic mouse modelbrain

   Brain DNA marks pointed to faster aging in structural epilepsy

   EBioMedicine·Nov 9, 2026

More on mTOR signaling

1. Epilepsy is associated with brain epigenetic age acceleration in humans (epilepsy).

   “Across lesion types and developmental stages, epileptic brain tissue exhibited robust epigenetic age acceleration.”

   Humansepilepsybrain

   Time flies faster in epilepsy

   Research Square·Feb 3, 2026Preprint

2. Epilepsy is associated with brain epigenetic age acceleration in mice (mutant epileptic mouse model of somatic mTOR pathway activation).

   “Mutant epileptic mouse brains recapitulated the human brain aging signatures, with minimal effects in blood and evidence that age acceleration emerged prior to seizure onset.”

   Animalsmutant epileptic mouse model of somatic mTOR pathway activationbrain

   Time flies faster in epilepsy

   Research Square·Feb 3, 2026Preprint

More on Epilepsy

1. Structural epilepsy is associated with brain epigenetic age acceleration in humans (structural epilepsy) (median +7.3 years).

   “In brain, epigenetic age acceleration was consistent across structural lesion types (median +7.3 years, p < 0.0001)”

   Humansstructural epilepsybrain

   Brain DNA marks pointed to faster aging in structural epilepsy

   EBioMedicine·Nov 9, 2026

More on Structural epilepsy