What does the research say about blood epigenetic age acceleration?

Blood epigenetic age acceleration

There is 1 paper on blood epigenetic age acceleration in aging research: 1 observational study in people. The newest story, Nov 9, 2026: “Brain DNA marks pointed to faster aging in structural epilepsy”.

Biomarker

1 paper studies it3 more mention it2 findings

1 new paper in 30 daysSee all 4 papers on blood epigenetic age acceleration

“except in FCD (+2.3 years, adj. p < 0.05)”

Epigenetic age acceleration in the brain and blood of people with epilepsy and in a mouse model of focal cortical dysplasia: a retrospective cross-sectional studyEBioMedicine2026doi:10.1016/j.ebiom.2026.106550

Humans1

Upstream

Epilepsy

no changein humans1

1 study

Epilepsy was not clearly linked with blood epigenetic age acceleration in humans (adjusted for cell composition, age, and sex) (median +0.7 years; p = 0.20).
“In blood, age acceleration was not significant after adjustment for cell composition, age, and sex (median +0.7 years, p = 0.20)”
Humansadjusted for cell composition, age, and sexblood
Brain DNA marks pointed to faster aging in structural epilepsy
EBioMedicineNov 9, 2026

Associations

Focal cortical dysplasia

upin humans1

1 study

Focal cortical dysplasia is associated with blood epigenetic age acceleration in humans (adjusted analysis) (+2.3 years; adjusted p < 0.05).
“except in FCD (+2.3 years, adj. p < 0.05)”
Humansadjusted analysisblood
Brain DNA marks pointed to faster aging in structural epilepsy
EBioMedicineNov 9, 2026

Latest

3 papers in 12 months

EBioMedicineNov 9

Brain DNA marks pointed to faster aging in structural epilepsy

In people with structural epilepsy, DNA-based age acceleration was greater in brain than blood, with median values of 7.3 versus 1.4 years.In people with structural epilepsy, DNA-based age acceleration was greater in brain than blood, with median values of 7.3 versus 1.4 years.

Cross-sectional studyEpilepsy