BOLD signal variance explained by physiological signals

Older age is associated with BOLD signal variance explained by physiological signals in humans.

“significant age-related reductions in the percent variance of the BOLD signal explained by heart rate (HR), respiratory variation (RV), and end-tidal CO2”

Humansbrain

The physiological component of the BOLD signal: Impact of age and heart rate variability biofeedback training

Imaging neuroscience (Cambridge, Mass.)·7 Aug 2025