Biologically distinct modes of brain aging

Biologically distinct modes of brain aging is associated with individual variation in brain aging rates in humans.

“we find that some modes do reflect aging rates varying strongly across subjects.”

HumansMultiple biologically distinct modes estimated; verified using two-timepoint UK Biobank databrainn = 4,400

Characterising ongoing brain aging and baseline effects from cross-sectional data

Imaging neuroscience (Cambridge, Mass.)·17 Jun 2025