Beta-hydroxy-beta-methylbutyrate

Age is linked with lower beta-hydroxy-beta-methylbutyrate in humans (β = -0.031, P = 0.018).

“inverse linear relationship between age and HMB levels (β = -0.031; P = 0.018)”

Humansplasman = 1,290

Association between endogenous plasma beta-hydroxy-beta-methylbutyrate levels and frailty in community-dwelling older people

Journal of cachexia, sarcopenia and muscle·Dec 13, 2023

Older-adults are linked with lower beta-hydroxy-beta-methylbutyrate in humans (-50% WBP, -25% concentration).

“reduction in WBP (50%; 1.23±0.15 vs. 0.69±0.06μmol/kgffm/h, p=0.001) and concentration (25%; 3.5±0.3μmol/l vs. 2.6±0.2μmol/l, p=0.01) for β-Hydroxy β-Methylbutyrate”

Humans

Metabolic phenotyping using kinetic measurements in young and older healthy adults

Metabolism: clinical and experimental·Oct 3, 2017

Beta-hydroxy-beta-methylbutyrate is associated with frailty in humans (older adults with type-2 diabetes mellitus) (OR 0.436, 95% CI 0.253–0.751, p-value 0.003).

“HMB levels showed an inverse cross-sectional association with frailty, which was modified when the interaction term HMB*glucose was included, remaining significant only for FTS12 [OR (95% CI): 0.436 (0.253, 0.751), p-value 0.003].”

Humansolder adults with type-2 diabetes mellitusplasman = 255

Relationship of endogenous plasma concentrations of β-hydroxy β-methyl butyrate (HMB) with frailty in community dwelling older adults with type-2 diabetes mellitus

The journal of nutrition, health & aging·Apr 9, 2024

Beta-hydroxy-beta-methylbutyrate is linked with a lower risk of frailty in humans.

“Frailty was associated with HMB levels in all the adjusted models, including the fully adjusted ones, no matter the tool used (odds ratio: 0.45 [0.26, 0.77] for FFP”

Humansplasman = 1,290

Association between endogenous plasma beta-hydroxy-beta-methylbutyrate levels and frailty in community-dwelling older people

Journal of cachexia, sarcopenia and muscle·Dec 13, 2023