Journal of Neuroinflammation
Lowering gene activity reduced brain inflammation in mice
In mice used to study Alzheimer’s disease, reducing the gene’s activity in brain immune cells also reduced amyloid deposits.In mice used to study Alzheimer’s disease, reducing the gene’s activity in brain immune cells also reduced amyloid deposits.
Mouse studyInflammation
Who was studiedMale APP/PS1-21 mice, against mice receiving scrambled control shRNA
What changedBrain inflammation markers fell in mice with reduced SPRY1 activity compared with mice receiving control shRNA
The catchOnly one shRNA was used, leaving possible off-target effects on other genes