Average Polycomb CpG Methylation

Cell proliferation rate is associated with Average Polycomb CpG Methylation in cells.

“This revealed that aging occurs at varying rates within specific cells, with faster proliferating cells showing accelerated levels.”

Cellsfaster proliferating cells

Cell-to-cell variability and gain of methylation at polycomb CpG islands as a hallmark of aging

bioRxiv (Cold Spring Harbor Laboratory)·11 Mar 2026Preprint

Average Polycomb CpG Methylation is associated with cellular aging in cells.

“Using single-cell whole-genome methylation data from multiple ages and tissues, we identify Average Polycomb CpG Methylation as a hallmark of cellular aging.”

Cells

Cell-to-cell variability and gain of methylation at polycomb CpG islands as a hallmark of aging

bioRxiv (Cold Spring Harbor Laboratory)·11 Mar 2026Preprint