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National Heart, Lung, and Blood InstituteUS$1.6mNational Institute on AgingUS$837.6k
Arterial Stiffening and Mechanics in Hutchinson-Gilford Progeria Syndrome
National Heart, Lung, and Blood InstituteUniversity of PennsylvaniaUS$28.5k2018–2021
National Heart, Lung, and Blood InstituteUniversity of Missouri-ColumbiaUS$106k2020–2024
Arterial stiffening and SMC mechanobiology in Hutchinson-Guilford Progeria Syndrome
National Institute on AgingUniversity of PennsylvaniaUS$393.4k2019–2024
Arterial Stiffening, Cerebrovascular Health, and Brain Aging
National Institute on AgingVanderbilt UniversityUS$22.1k2018–2019
In 17 human thoracic aorta samples, elastin stiffness, straightness, and lamellar length decreased significantly with age in males (p < 0.05) but not females.In 17 human thoracic aorta samples, elastin stiffness, straightness, and lamellar length decreased significantly with age in males (p < 0.05) but not females.
Ex vivo tests in young and old mice showed that intact perivascular fat increased aortic stiffness only in older animals, alongside higher fat collagen levels.Ex vivo tests in young and old mice showed that intact perivascular fat increased aortic stiffness only in older animals, alongside higher fat collagen levels.