ArtAgeGap

1. ArtAgeGap raises the risk of stroke in humans.

   “higher ArtAgeGap elevating the risks of coronary heart disease and stroke.”

   HumansMendelian randomization analysis

   A photoplethysmography-based aging clock reveals genetic determinants of arterial aging

   medRxiv·17 Nov 2025Preprint

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1. ArtAgeGap raises the risk of coronary heart disease in humans.

   “higher ArtAgeGap elevating the risks of coronary heart disease and stroke.”

   HumansMendelian randomization analysis

   A photoplethysmography-based aging clock reveals genetic determinants of arterial aging

   medRxiv·17 Nov 2025Preprint

More on Coronary heart disease

1. ArtAgeGap predicts mortality in humans.

   “higher ArtAgeGap values predicted incident hypertension, major adverse cardiovascular events, and cardiovascular and all-cause mortality”

   HumansPrediction beyond chronological ageMedian 13 yearsn = 96,615

   A photoplethysmography-based aging clock reveals genetic determinants of arterial aging

   medRxiv·17 Nov 2025Preprint

1. Hyperlipidemia is associated with ArtAgeGap in humans (+0.49 years, 95% CI 0.36–0.61).

   “associated with diabetes (+0.93 years, 95%CI: 0.64-1.21) and hyperlipidemia (+0.49, [0.36-0.61]).”

   Humans

   A photoplethysmography-based aging clock reveals genetic determinants of arterial aging

   medRxiv·17 Nov 2025Preprint

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1. Diabetes is associated with ArtAgeGap in humans (+0.93 years, 95% CI 0.64–1.21).

   “associated with diabetes (+0.93 years, 95%CI: 0.64-1.21)”

   Humans

   A photoplethysmography-based aging clock reveals genetic determinants of arterial aging

   medRxiv·17 Nov 2025Preprint

More on Diabetes

1. ArtAgeGap is associated with pulse pressure in humans (r = 0.60).

   “which correlated with established measures of vascular stiffening, such as pulse pressure ( r =0.60).”

   Humans

   A photoplethysmography-based aging clock reveals genetic determinants of arterial aging

   medRxiv·17 Nov 2025Preprint

More on Pulse pressure