APOE ε2 allele frequency

Cognitively healthy centenarian status is associated with APOE ε2 allele frequency in humans (2.1-fold enrichment; p = 4.8 × 10−7).

“The cohort was 2.1-fold enriched with the neuroprotective APOE-ε2 allele relative to 60-80 year-old population controls”

HumansCognitively healthy centenarians compared with 60–80-year-old population controls

The 100-plus Study of cognitively healthy centenarians: rationale, design and cohort description

European journal of epidemiology·Oct 25, 2018