Apnea-hypopnea index in REM sleep

1. Apnea-hypopnea index in REM sleep increases white matter hyperintensities volume in humans (OR = 1.18, 95% CI 1.02 to 1.36).

   “Higher AHI in REM sleep and mean oxygen saturation<94% (the median value of study sample) were independently associated with greater WMH volume: odds ratio AHI in REM sleep per 1‐SD increase = 1.18 (95%CI, 1.02 to 1.36, p = 0.048)”

   Humansn = 842

   Sleep macro‐architecture, nocturnal hypoxemia, and Alzheimer’s Disease‐related MRI patterns among diverse older adults

   AAIC 2025 abstract·23 Dec 2025

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