AgingResearch.NewsJoin free

Anti-spike antibody titers

Biomarker

2 papers study it3 findings

  • Humans2

Upstream

1

Frailty

downin humans2

2 studies

  1. Frailty decreases anti-spike antibody titers in humans (10-fold higher in individuals with lower frailty status (p = 0.001 and p = 0.005, unadjusted and adjusted for prior COVID-19 infection)).

    “anti-spike antibody titers were 10-fold higher in individuals with lower frailty status”

    Human trialn = 15

    Frailty impacts immune responses to Moderna COVID-19 mRNA vaccine in older adults

    Immunity & ageing : I & AJan 17, 2023

  2. Frailty decreases anti-spike antibody titers in humans (5-fold higher in mild vs severe).

    “anti-spike antibody titers were higher in 5-fold higher in individuals with mild frailty compared to severe frailty”

    Human trialafter 2 vaccine dosesn = 15

    Frailty and Age Impact Immune Responses to Moderna COVID-19 mRNA Vaccine

    Research squareAug 1, 2022Preprint

Associations

1

CD8+ CD28- TEMRA cells

downin humans1

1 study

  1. CD8+ CD28- TEMRA cells are associated with anti-spike antibody titers in humans (p = 0.036).

    “Overall antibody response was inversely correlated with a phenotype of immune-senescent T cells, CD8 + CD28- TEMRA cells (p = 0.036, adjusted for COVID-19 infection).”

    Human trialn = 15

    Frailty impacts immune responses to Moderna COVID-19 mRNA vaccine in older adults

    Immunity & ageing : I & AJan 17, 2023

More on CD8+ CD28- TEMRA cells

Latest

Related