3 papers4 findings
Cognitive decline
upin humans1OR 1.068
Allostatic load index is associated with cognitive decline in humans (OR = 1.068).
“In the ReDLat cohort, higher ALI correlated with worse clinical cognitive status (OR = 1.068; p = 0.031).”
HumansReDLat cohort
The Role of Allostatic Load in Cognitive Impairment and Dementia in Latin America Population
AAIC 2025 abstract26 Dec 2025
Cognitive impairment
upin humans1OR 1.048
Allostatic load index raises the risk of cognitive impairment in humans (OR = 1.048).
“In Costa Rica, ALI was significantly associated with cognitive impairment (OR = 1.048; p = 0.021).”
HumansCosta Rica cohort
The Role of Allostatic Load in Cognitive Impairment and Dementia in Latin America Population
AAIC 2025 abstract26 Dec 2025
Morbidity
upin humans1
Allostatic load index predicts morbidity in humans.
“numerous studies have demonstrated greater prediction of morbidity and mortality over and beyond traditional detection methods”
Review
Allostatic load biomarkers of chronic stress and impact on health and cognition
Neuroscience and biobehavioral reviews12 Oct 2009
Mortality
upin humans1
Allostatic load index predicts mortality in humans.
“numerous studies have demonstrated greater prediction of morbidity and mortality over and beyond traditional detection methods”
Review
Allostatic load biomarkers of chronic stress and impact on health and cognition
Neuroscience and biobehavioral reviews12 Oct 2009
Participants in the highest quartile of allostatic load had over double the cancer risk compared to the lowest quartile, showing an odds ratio of 2.24.Participants in the highest quartile of allostatic load had over double the cancer risk compared to the lowest quartile, showing an odds ratio of 2.24.