AIRE-DD

1. AIRE-DD predicts diastolic dysfunction in humans (C-index 0.751 (95% CI 0.719–0.791)).

   “For incident DD prediction in BIDMC participants without baseline DD and LVEF ≥ 50 %, AIRE-DD achieved a C-index of 0.751 (95 % CI 0.719–0.791).”

   HumansBIDMC participants without baseline DD and LVEF ≥ 50 %

   AI-enhanced ECG for diastolic dysfunction: development, validation and prognosis across five international cohorts

   AHA Scientific Sessions 2025 abstract·3 Nov 2025

More on Diastolic dysfunction

1. AIRE-DD raises the risk of mortality in humans (HR 1.67 (1.33–2.09)).

   “Across BIDMC, CODE, ELSA-Brasil and UKB, AIRE-DD-predicted increased filling pressures were associated with age- and sex-adjusted HRs for all-cause mortality of 2.05 (1.87–2.26), 2.83 (2.75–2.92), 4.38 (3.46–5.52) and 1.67 (1.33–2.09), respectively.”

   HumansUK Biobank cohort, age- and sex-adjusted

   AI-enhanced ECG for diastolic dysfunction: development, validation and prognosis across five international cohorts

   AHA Scientific Sessions 2025 abstract·3 Nov 2025

1. AIRE-DD predicts heart failure with preserved ejection fraction in humans (AUC 0.850 (0.809–0.887)).

   “In KCH, AIRE-DD identified clinician-confirmed HFpEF with an AUC of 0.850 (0.809–0.887).”

   HumansKCH cohort

   AI-enhanced ECG for diastolic dysfunction: development, validation and prognosis across five international cohorts

   AHA Scientific Sessions 2025 abstract·3 Nov 2025

More on Heart failure with preserved ejection fraction

1. AIRE-DD predicts increased LV filling pressures in humans (AUC 0.883 (95% CI 0.874–0.891)).

   “AIRE-DD detected increased LV filling pressures with an AUC of 0.883 (95 % CI 0.874–0.891), sensitivity 0.780, specificity 0.822, PPV 0.564 and NPV 0.927.”

   HumansBIDMC holdout set

   AI-enhanced ECG for diastolic dysfunction: development, validation and prognosis across five international cohorts

   AHA Scientific Sessions 2025 abstract·3 Nov 2025