1 paper studies it28 more mention it4 findings
Calcium alpha-ketoglutarate
downin humans1
Calcium alpha-ketoglutarate is associated with Age Residual in humans.
“In a longitudinal subset, intake of coenzyme Q10 (CoQ10) and dAKG was associated with increased odds of a lower Age Residual”
HumansLongitudinal subset; not significant after multivariate correctiondelayed-release
Aging cellMay 21, 2026
Coenzyme Q10
downin humans1
Coenzyme Q10 is associated with Age Residual in humans.
“In a longitudinal subset, intake of coenzyme Q10 (CoQ10) and dAKG was associated with increased odds of a lower Age Residual”
HumansLongitudinal subset; not significant after multivariate correction
Aging cellMay 21, 2026
Antihistamines
downin humans1
Antihistamines are associated with Age Residual in humans.
“Among medications, there was a non-significant benefit of antihistamine use, although the analysis was sample-size limited.”
HumansHealth enthusiasts; sample-size-limited analysis
Aging cellMay 21, 2026
Calcium alpha-ketoglutarate + vitamins
downin humans1
Calcium alpha-ketoglutarate + vitamins are associated with Age Residual in humans (1.8-year lower Age Residual).
“a commercially available, delayed-release calcium-alpha-ketoglutarate (dAKG) + vitamin supplement ("Rejuvant") was associated with an average 1.8-year lower Age Residual.”
HumansHealth enthusiasts; cross-sectional analysisdelayed-release calcium-alpha-ketoglutarate + vitamin supplementn = 4,260
Aging cellMay 21, 2026
A DNA-methylation measure of pubertal development correlates with established epigenetic clocks and predicts mortality and disease in two large adult cohorts.A DNA-methylation measure of pubertal development correlates with established epigenetic clocks and predicts mortality and disease in two large adult cohorts.