Age-associated CpG methylation

Age is associated with age-associated CpG methylation in M. californianus (thousands of age-associated differentially methylated loci).

“We identified thousands of age-associated differentially methylated loci with directional changes across age classes”

Model organismsacross age classesn = 7

Integrated Genomic and Methylome Profiling Reveals Promoter Repression and Age-Linked CpGs in the California Mussel

bioRxiv (Cold Spring Harbor Laboratory)·1 Sep 2025Preprint

Age-associated CpG methylation is associated with age in silico (19,432 age-associated CpGs).

“We then identified 19,432 age-associated CpGs (aaCpGs) that were strongly correlated with age and showed high consistency between sexes”

In silicon = 4,641

Age-Related Patterns of DNA Methylation Changes

bioRxiv (Cold Spring Harbor Laboratory)·12 Dec 2024Preprint

Chronological age is associated with age-associated CpG methylation in humans (3,467 age-associated CpGs at FDR < 0.05).

“The analysis identified 3,467 age-associated CpGs at FDR < 0.05, with an overall hypomethylation bias but focal hypermethylation at canonical aging loci.”

HumansPost-COVID individuals; cross-sectional analysis adjusted for sexwhole bloodSix months after COVID-19 infection

DNA Methylation at Core NMDA Receptor Genes Reveals a Glutamatergic Signature of Aging in Post-COVID Whole Blood with Implications for Long COVID Neuropsychiatric Sequelae

Figshare·1 Jul 2026Preprint

Age-associated CpG methylation is associated with H4K20me3- and H3K9me3-marked heterochromatin in X. tropicalis.

“CpG sites with methylation levels significantly increasing or decreasing with age are enriched in heterochromatic regions marked with H4K20me3 and H3K9me3.”

Animalsn = 192

An epigenetic clock for Xenopus tropicalis reveals age-associated sites enriched in H4K20me3-marked heterochromatin

bioRxiv (Cold Spring Harbor Laboratory)·22 Dec 2024Preprint